Karen Sue Manker, 63, of Tucson, AZ, died Monday, Oct. 11, 2021, at her home. She was born May 9, 1958, in Jacksonville, IL the daughter of Richard L. and Eileen D. Littig DeFrates. She married Phillip A. Manker on Feb. 18, 1978, in Jacksonville and he survives. She is also survived by one brother, Gary (Kathy) DeFrates of Jacksonville. She was preceded in death by her parents; and one brother, Gail DeFrates (surviving wife Debbie of Texas.) Mrs. Manker had worked with her mother for Dr. Walter Frank in Jacksonville, and she later worked for AJ Spreen Plumbing Inc. She loved to sew and cook. Karen loved the Soutwest, where she and Phillip spent the past 22 years living in Tucson. A private service will be held with burial at Neelyville Trinity Lutheran Church Cemetery. The Buchanan & Cody Funeral Home in Jacksonville is in charge of the arrangements. Condolences may be left at buchanancody.com. .